![]() Springer-Verlag GmbH Germany, part of Springer Nature. The underlying connecting mechanism remains undetermined, yet.Īura Migraine Transient global amnesia Transient ischemic attack. Ī significant association between TGA and migraine was established. Finally, pooled findings from four case-control studies of moderate-quality revealed a higher prevalence of migraine among TGA compared to TIA patients. Additionally, pooled data from eight case-control studies (700 TGA, 746 HC) yielded similar results, with the association mainly driven by the three high-quality studies, rather than the five articles of moderate quality. Sensitivity testing based on stricter diagnostic criteria strengthened the estimated association. The high-quality, population-based, retrospective cohort (158,301 participants per group) determined a higher relative-risk (RR) of TGA for migraine vs. The nationwide inpatient cross-sectional study was of lesser value due to its inpatient orientation. Results from case-control (ten), cohort (one) and cross-sectional (one) studies were compatible with an association between TGA and migraine. Literature search yielded 1178 articles, 12 of which were included in the present meta-analysis. Data from case-control, cross-sectional and cohort studies were pooled separately. healthy controls (HC), as well as in TGA against TIA individuals. The prevalence of migraine was compared in TGA patients vs. Quality evaluation was based on the Newcastle-Ottawa scale. Observational controlled studies including TGA patients (Caplan, Hodges and Warlow) were retrieved. Literature search involved MEDLINE, EMBASE, CENTRAL and PsycINFO. doi:10.PURPOSE: Although many studies have investigated the relationship between transient global amnesia (TGA) and migraine, to date, no meta-analysis has confirmed the existence and size of their association. Transient Global Amnesia (TGA) is a temporary anterograde amnestic syndrome characterized by the lack of other focal neurological signs or symptoms (Hodges and Warlow, 1990a). Acute-Onset Amnesia: Transient Global Amnesia and Other Causes. What Does Transient Global Amnesia Really Mean? Review of the Literature and Thorough Study of 142 Cases. Quinette P, Guillery-Girard B, Dayan J et al. Transient Global Amnesia: Diffusion-Weighted Imaging Lesions and Cerebrovascular Disease. Optimal Diffusion-Weighted Imaging Protocol for Lesion Detection in Transient Global Amnesia. High-Resolution Diffusion-Weighted Imaging Increases Lesion Detectability in Patients with Transient Global Amnesia. Post-traumatic amnesia, has a history of trauma 6 Psychogenic amnesia, more-so affects semantic memory compared to episodic memory, while TGA is the opposite 6ĭrug-related amnesia, typically has features of encephalopathy 6 Transient epileptic amnesia, typically presents upon waking while TGA does not 6 Intracerebral hemorrhages usually develop during minutes and. Other disorders that have acute onset and cause persistent focal signs should be considered in the differential diagnosis. hippocampal ischemic), typically exists with other neurological deficits 6 Ischemic strokes are characterized by the abrupt or at least very acute onset of focal neurologic symptoms and signs that leave persistent neurologic deficits. The condition rarely recurs in ~5% of patients 5,6. These changes generally appear after symptom resolution, and the highest rate of detection is approximately 2 days after symptom onset 6. These lesions can be bilateral and even multifocal 2-4. Prospective and retrospective studies based on a small number of transient global amnesia patients can detect small punctate regions of abnormally restricted diffusion on DWI/ADC sequences in the CA1 area of the hippocampus (lateral edge of the hippocampal gyrus abutting the temporal horn). Radiographic featuresĬT brain and conventional sequences of MRI brain may show no abnormalities, especially while the patient is symptomatic. epileptic phenomena, stroke, focal ischemia) have been proposed with no consensus on the exact mechanism 1,6. Most cases show complete resolution of symptoms within a few hours from onset of symptoms 6. Episodic memories are more-so affected than semantic memories 6. ![]() AssociationsĪnterograde and partial retrograde amnesia lasting less than 24 hours without any other neurological or congestive symptoms 6. ![]() Transient global amnesia is most common in the 50-70 year age range ref. ![]()
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